The country has invested hundreds of millions of dollars into research on induced pluripotent stem cells to treat diseased organs.
, a condition in which eyesight deteriorates progressively. In those studies, the retinal cells seemed to survive the transplants and the participants’ vision did not get worse — a sign of success, says Takahashi. But scientists say it is difficult to show whether the cells contributed to slowing vision deterioration.
In Japan, the observed beneficial effect of the cells has boosted scientists’ morale. “I’m very happy that the cornea could show that now,” says Takahashi. The results are very important for regenerative medicine in Japan, she says. The case report is important and it is good to see that the trial participant did not develop tumours or an irregular heartbeat, says Zimmermann, who is also running a trial using iPS-cell-derived heart muscle cells. But it is not clear whether any observed improvements in symptoms were a direct result of the transplanted cells or due to other aspects of the surgery.
Takahashi has heard that the government’s next budget for regenerative medicine will be reduced, which will have a flow on effect. In Japan, there are currently too many people in the field for the amount of investment that’s available, says Jeanne Loring, a stem-cell researcher at Scripps Research in La Jolla, California. “Not everybody can sort of break through.
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