Pfizer's Oxbryta exit may hasten trials of rival experimental sickle cell drugs, analysts say

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Pfizer's Oxbryta exit may hasten trials of rival experimental sickle cell drugs, analysts say
Wall Street AnalystsSickle Cell DiseaseAgios Pharmaceuticals
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Pfizer's decision late on Wednesday to withdraw its sickle cell disease treatment due to the risk of death could help speed up trials of new experimental...

- Pfizer 's decision late on Wednesday to withdraw its sickle cell disease treatment due to the risk of death could help speed up trials of new experimental rivals, Wall Street analysts said.

At least three Wall Street brokerages said the withdrawal could create an immediate need to accelerate trials of rival drugs for the inherited condition, including Agios Pharmaceuticals' mitapivat and Fulcrum Therapeutics' pociredir.In case of Agios, it could create pressure on regulators to speed up the review, Piper Sandler analysts said.

Pfizer's shares were marginally down on Thursday. The stock is trading at around half its pandemic highs. At least five African countries are working on what could be the world's first joint "debt-for-nature" swap to raise at least $2 billion to protect a coral-rich swathe of Indian Ocean, according to a global conservation group. Debt-for-nature deals are becoming increasingly popular for poorer nations to pay for conservation. Bonds or loans are bought and replaced with cheaper debt, with savings used for environmental protection.

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Wall Street Analysts Sickle Cell Disease Agios Pharmaceuticals Fulcrum Therapeutics Clinical Trials European Medicines Agency Oxbryta CRISPR Therapeutics Piper Sandler

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