Pelargonidin and Berry Intake Association with Alzheimer’s Disease Neuropathology: A Community-Based Study - IOS Press

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Pelargonidin and Berry Intake Association with Alzheimer’s Disease Neuropathology: A Community-Based Study - IOS Press
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Strawberries may fend off Alzheimer's IOSPress_STM

[*] Correspondence to: Puja Agarwal, Rush University Medical Center, 1750 W Harrison st, ST 1000, Chicago, IL 60612, USA. Tel.: 312-947-7232; E-mail:Background:An anthocyanidin, pelargonidin, primarily found in berries, has antioxidant and anti-inflammatory properties, and is associated with better cognition and reduced Alzheimer’s dementia risk.

sease neuropathology in human brains. Methods:The study was conducted among 575 deceased participants of the Rush Memory and Aging Project, with dietary data and neuropathological evaluations. Calorie-adjusted pelargonidin intake was modeled in quartiles and berry intake as continuous . Mean amyloid-beta load and phosphorylated tau neuronal neurofibrillary tangle density across multiple cortical regions were assessed using immunohistochemistry.

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