Researchers have unveiled an intriguing phenomenon of cellular reprogramming in mature adult organs, shedding light on a novel mechanism of adaptive growth. The study, which was conducted on fruit flies (Drosophila), provides further insights into dedifferentiation—where specialized cells that have specific functions transform into less specialized, undifferentiated cells like stem cells. The study is published in the journal Developmental Cell.
activates the JAK-STAT signaling pathway in EEs, facilitating the conversion of EEs into ISCs during post-starvation recovery. When combined with findings from other studies, this implies that the nutrient-dependent dedifferentiation could be an evolutionary conserved mechanism across species.
Representative image of a dedifferentiating EE which is brightly shining like a star. This is a fluorescent confocal microscope image in which the dedifferentiating EE is shown as a cell with white color . Green indicates expression of stemness marker, magenta marks cells that are originally derived from EEs, and blue indicates expression of EE marker. The white color means that this cell lost identity as EEs and converted into a stem cell.
Yuichiro Nakajima, also formerly based at FRIS and corresponding author of the paper, states that this could lead to being able to control artificial cellular reprogramming in vivo."If we figure out specific nutrients and the detailed signaling that induce dedifferentiation, we could control cell fate plasticity by nutritional intervention and/or pharmacological treatments"
Looking ahead, they hope to focus on examining cell fate plasticity under physiological conditions beyond nutrition, such as reproduction, temperature, light, and exercise. Doing so may uncover novel mechanisms underlying environmental adaptations.Hiroki Nagai et al, Nutrient-driven dedifferentiation of enteroendocrine cells promotes adaptive intestinal growth in Drosophila,
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