More than 100 top scientists including 15 Nobel laureates have written an open letter calling for volunteers to be exposed to the coronavirus to assist with vaccine development.
They said so-called "human challenge trials" or "controlled infection trials" were of "vast importance" in speeding up the testing of the vaccines in development around the world.
Oxford's Jenner Institute is working with 1Day Sooner to produce a COVID-19 human challenge virus and Hill said it had "considerable potential" for helping to accelerate vaccine development and optimize vaccination approaches.in May saying challenge studies can be "substantially faster" and more effective than other methods, in part because fewer participants need to be exposed to experimental vaccines and because they can be used to compare potential vaccines.
It said controlled infection trials could be ethically acceptable if they met certain criteria. These include choosing young and healthy adults as participants, starting with low doses, ensuring public engagement, and providing high-quality care and close monitoring.for COVID-19 was jump-started by a March 31 article in the Journal of Infectious Diseases, which made the case that the nature of the global emergency warranted consideration of unconventional approaches.
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