Although routinely recommended, nicotinamide does not prevent nonmelanoma skin cancers in solid-organ transplant patients, according to a randomized trial.
Transplant patients have 50 times the risk of nonmelanoma skin cancers ― also known as keratinocyte cancers ― than the general public, owing to immunosuppression, and their lesions are more aggressive and are more likely to metastasize, they explain.
At 12 months, there was virtually no difference in the incidence of new nonmelanoma skin cancers: 207 in the nicotinamide group and 210 in the placebo group . As for why nicotinamide didn't work in the trial, the investigators say it could be because it is not potent enough to overcome the stifling of antitumor immunity and DNA-repair enzymes with immunosuppression.
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