Next-gen CRISPR technology could soon bring new therapies for genetic diseases, as well as nutritious, climate-resilient crops. [Sponsored by KavliPrize]
The practice of genetic modification is as old as humanity. For thousands of years, humans have bred crops, livestock and even pets that possess desirable traits. This selective process, which alters an offspring’s genome, began long before anyone knew of genes or DNA, and it has shaped the course of human civilization.
Will we be able to use CRISPR as a drug to treat human disease? There is great interest in this. Right now, CRISPR is being developed to treat certain blood disorders like sickle-cell disease. In that case, hematopoietic stem cells are harvested from the patient, and the disease-related gene is edited with CRISPR outside the body, before the cells are given back to the patient.
The practice of genetic modification is as old as humanity. For thousands of years, humans have bred crops, livestock and even pets that possess desirable traits. This selective process, which alters an offspring’s genome, began long before anyone knew of genes or DNA, and it has shaped the course of human civilization.
How can CRISPR be used to improve agriculture? CRISPR offers the possibility of engineering plant crops that will help us face the challenges of climate change. One approach is to challenge plants with the types of stresses we think will be encountered in the future, such as rising temperatures and drought. Researchers then sequence the genomes of the plants that can resist those stresses and identify the mutations that confer resistance.
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