From timing of medications to supplement use, Dr Anne Peters reviews several recent studies that have changed beliefs in the realm of cardiovascular disease. EASD2022
Recently, there have been a series of published studies in the realm of cardiovascular disease that have changed certain beliefs we've held in the past. I'm going to review a few of these.. The TIME study looked at whether it matters if you give antihypertensive agents in the morning or the evening.
At the meeting of the American Society of Nephrology, results from a study on the use of renin–angiotensin system inhibitors in advanced CKD was presented, called the. Again, another interesting trial asking a simple question. This was a randomized controlled trial in patients who had an estimated glomerular filtration rate < 30, and they were randomized to stop or continue therapy with their RAS inhibitors.
We used to put having diabetes in that same high-risk category as people who'd already had a cardiovascular disease event. Well, have we made that any different? These authors are from Canada, and they did a retrospective population-based study looking at administrative health claims from Ontario, Canada, to assess the association of diabetes and prior cardiovascular disease with cardiovascular events from 1994 to 2014.
I think this is good news because diabetes itself isn't as high a cardiovascular risk factor as we once thought. It doesn't mean that it isn't a cardiovascular risk factor, but I think we've done better at mitigating the risk.Journal of the American College of Cardiology The agents studied were rosuvastatin, placebo, fish oil, cinnamon, garlic, turmeric, plant sterols, and red yeast rice. Well, not surprisingly, rosuvastatin worked. It showed a 35% reduction in LDL cholesterol, and there was no significant impact on cholesterol levels with any of the other agents. The supplements yielded a similar response, as did the placebo. Side effects were similar, but they were most common with plant sterols and red yeast rice.
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