New Insight Into Nanoassemblies for Specific Cancer Therapy: Biomaterials_ nanomedicine cancer nanoassemblies nanotechnology nanoscience
By Bhavna KavetiJul 26 2022Reviewed by Susha Cheriyedath, M.Sc. Although retinoic acid can induce cell death, its weak anticancer efficacy limits its clinical applications. To this end, stimulus-responsive self-assembling prodrug-based nanomedicines are promising candidates that enable controlled drug delivery.
The self-assembling prodrug-based drug delivery is beneficial for the excellent anticancer efficacy of RABA nanoassemblies. This strategy has provided new insight into the designing and development of self-immolating prodrug nanoassemblies for target-specific cancer therapy. RA plays a vital role in cell growth and differentiation and induces cancer cell apoptosis via cytotoxic activities. Moreover, RA is anticipated to enhance the efficacy of immune checkpoint inhibitors and antiangiogenic therapies. However, RA is inefficient in inducing cancer cell apoptosis compared to traditional anticancer drugs.
Since γ poly-glutamic acid was previously reported to bind to gamma-glutamyl transferase with a high affinity, the RABA was coated with γ-PGA leading to tRABA nanoassemblies as drug delivery systems, employed as cancer-targeted nanomedicines. The synthesized tRABA nanoassemblies had a negative surface charge of -31 millivolts at pH 7.
Canada Latest News, Canada Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
AMD invests in a new CPU R&D facility in New YorkThis is a big investment in USA based chip development.
Read more »
Spain introduces new £85 rule for British holidaymakers entering countryBritish holidaymakers now face new restrictions to enter the country as the Spanish Ministry introduces new rules.
Read more »
Lena Dunham's bold new film on female sexuality, Sharp Stick: here's everything you need to knowUncomfortable, awkward but also sexy - Sharp Stick is about to be an interesting watch 👀
Read more »
Russia’s New Gas Deals With Iran Are A Threat To The West | OilPrice.comGazprom’s $40 billion MoU with Iran’s NIOC includes a number of strategically important gas and LNG deals that are aimed at putting the squeeze on the West
Read more »
New Adult Disability Payment guide could help people claim up to £156 each weekSuccessful claimant’s in 13 council areas could receive between £97.80 and £627.60 every four weeks.
Read more »
Countryfile presenter to host new Radio 5 Live show broadcast from LeedsHelen Skelton has been confirmed as the new host of a Radio 5 Live Sunday morning slot to be broadcast from Leeds.
Read more »