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A paradigm shift is underway in the treatment of acute myeloid leukemia: The newest of personalized medicines proved more effective and less toxic than standard chemotherapy for certain acute myeloid leukemia patients, new research indicates.
Acute myeloid leukemia, often called AML, is a type of blood and bone marrow cancer. Patients with a mutation of the FLT3 gene -- about 30% of all AML patients -- have a higher risk of relapse. The new research involved patients with relapsed or refractory AML who tested positive for the FLT3 mutation.In a clinical trial, rates of complete remission were 34% for those receiving the new drug, gilteritinib, compared with just 15.3% for those given standard chemotherapy, explained Dr.
Nichols, who also was not involved in the study, said the FDA is looking at other drugs for AML, but the"bottom line" is that FLT3-positive AML is a"bad prognosis," so it is"good to have several options now showing better efficacy as compared to standard care." Nichols noted that The Leukemia & Lymphoma Society's is conducting a clinical trial testing gilteritinib as a frontline therapy for AML patients.
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