Scientists have developed a specially formulated bioink, which contains microparticles engineered for sustained delivery of insulin-like growth factor-1 (IGF-1). This delivery enhances the formation of mature skeletal muscle tissue from muscle precursor cells and facilitates their structural alignment, leading to more efficient regeneration of functional skeletal muscle tissue. This, in turn, can lead to successful therapies for people suffering from muscle loss or injury.
An advancement in 3D bioprinting of native-like skeletal muscle tissues has been made by scientists at the Terasaki Institute for Biomedical Innovation . The key to the TIBI scientists' approach lies in their specially formulated bioink, which contains microparticles engineered for sustained delivery of insulin-like growth factor-1 .
The normal process for muscle development is gradual, where round muscle precursor cells called myoblasts fuse to form tubular-shaped cells called myotubes. These myotubes eventually develop into mature muscle fibers. In addition to muscle cell maturation, precise cellular alignment and orientation are essential to successful muscle contraction and function.
The TIBI approach utilizes 3D bioprinting with a bioink composed of GelMA , myoblast cells, and microparticles engineered for sustained delivery of IGF-1. One week after the muscle constructs were created with the new bioink, the researchers observed enhanced myoblast alignment, fusion, and differentiation into myotubes, which were also shown to grow and elongate significantly more than constructs without a sustained release of IGF-1. Interestingly, ten days after bioprinting, the muscle tissue constructs having sustained release of IGF-1 began to contract spontaneously.
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