Nature’s Alchemy: Cellular Waste Transformed Into Essential Chemicals — A recent study uncovers a |
article, researchers revealed a previously unknown biochemical recycling process in animals that uses cellular waste to produce new, vital chemicals. These chemicals play important roles in regulating behavior, development, and aging. Contrary to previous belief, genes thought to code for carboxylesterases, enzymes that hydrolyze esters, actually assemble a variety of new metabolites from cellular waste.
These studies show that the genes previously thought to code for carboxylesterases, enzymes that hydrolyze esters, actually play a pivotal role in assembling a wide range of new metabolites from building blocks generally considered “cellular waste.” Surprisingly, the so-called carboxylesterases were found to contribute to the formation of esters and amide bonds, a function opposite to that predicted by computational algorithms.
Recent investigations indicate that animals and humans may produce over 100,000 distinct chemicals, most of which have not been investigated. This unknown structure space is a treasure trove of chemicals, which may hold the key to understanding many biological processes. One major challenge to understanding how these metabolites contribute to survival is that the enzymes that produce them are also unknown.
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