Nasal COVID Treatment Shows Early Promise Against Multiple Variants

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Nasal COVID Treatment Shows Early Promise Against Multiple Variants
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An antiviral therapy in early development has the potential to prevent or treat COVID-19 infection when given as a nasal spray in as little as 4 hours before or after exposure.

March 31, 2023 – An antiviral therapy in early development has the potential to prevent COVID-19 infections when given as a nasal spray as little as 4 hours before exposure. It also appears to work as a treatment if used within 4 hours after infection inside the nose, new research reveals.

Unlike a COVID vaccine that boosts a person’s immune system as protection, the antiviral nasal spray works more directly by blocking the virus, acting as a"biological mask in the nasal cavity," according toThe product targets a stable site on the spike protein of the virus that is not known to mutate. This same site is shared among many variants of the COVID virus, so it could be effective against future variants as well, researchers note.

“TriSb92 could effectively tip the balance in favor of the [the person] and thereby help to reduce the risk of severe COVID-19 disease,” she said.“Many elderly people as well as individuals who are immunodeficient for various reasons do not respond to vaccines, and are in the need of other protective measures,” said Kalle Saksela, MD, PhD, senior author of the study and a virologist at the University of Helsinki.

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