A component of the milk consumed by newborn mice triggers a crucial shift in heart cells’ metabolism.
Heart-muscle cells develop a taste for lipids thanks to a fatty acid in mother’s milk, mouse experiments show.Heart-muscle cells are endurance athletes, capable of beating for a lifetime. Now, scientists studying mice have discovered how these cells reach their full powers: with the help of mother’s milkThe research shows that a molecule in milk prompts a newborn mouse’s heart-muscle cells to shift to a different food source, which then powers the cells through adulthood.
To determine which molecules were responsible for this outcome, the researchers milked mother mice by hand and analysed the milk’s components. The team zeroed in on a fatty acid called ɣ-linolenic acid , which is also found in human breast milk. Neither mice nor humans can make GLA and must ingest it in the diet.
Working out this chain of events took more than seven years of effort, including the development of a new type of ‘knockout’ mice that lack the key RXR receptor to which GLA binds. Adding to the complexity was the need to work with newborn mice, which are challenging to study because of their small size and the uncertain timing of their birth, Paredes says.
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