Monkeypox: 'Anarchic' Vaccination or Clinical Trials?

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Monkeypox: 'Anarchic' Vaccination or Clinical Trials?
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Public health officials in Argentina questioned the logic of vaccination programs in countries like the United States. They proposed that doses be given within the context of clinical trials.

BUENOS AIRES, Argentina — Vaccinating against monkeypox can complement other public health measures aimed at containing the current outbreak in nonendemic countries. However, when it comes to the need to immunize now, we need to"calm down," according to officials and experts at a meeting organized by Argentina's Ministry of Health. Another issue to be considered is whether doses should be given within the framework of clinical trials so that evidence can be built up, they said.

"There's use because there's demand by certain groups…For example, at the most recent International AIDS Conference in Montreal, there was a sense of anarchy with how whoever wanted to be vaccinated was being vaccinated — and all of this when there are harsh restrictions when it comes to accessing the supply of the vaccine," Orduna said.

Also set forth was the recommendation to"Consider the targeted use of vaccines for pre-exposure prophylaxis in persons at risk of exposure; this may include health workers at high risk of exposure, laboratory personnel working with orthopoxviruses, clinical laboratory personnel performing diagnostic testing for monkeypox, and communities at high risk of exposure or with high-risk behaviors, such as persons who have multiple sexual partners.

Nevertheless, the WHO Director-General recommended that states "make all efforts to use existing or new vaccines against monkeypox within a framework of collaborative clinical efficacy studies, using standardized design methods and data collection tools for clinical and outcome data, to rapidly increase evidence generation on efficacy and safety, collect data on effectiveness of vaccines , and conduct vaccine effectiveness studies.

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