Moderna COVID vaccine is more effective in older and sicker veterans over time Coronavirus Disease COVID Vaccine OFIDJournal
By Dr. Liji Thomas, MDJul 28 2022Reviewed by Benedette Cuffari, M.Sc. A new Open Forum Infectious Diseases study reports the higher effectiveness of the Moderna messenger ribonucleic acid coronavirus disease 2019 vaccine as compared to the Pfizer/BioNTech mRNA COVID-19 and Johnson & Johnson viral vector vaccines against all outcomes of SARS-CoV-2 infection.
Study findings Using the VA’s COVID-19 Shared Data Resource with a cohort of approximately five million veterans with a mean age of 64 years, 42% and 14% were 65 and 80 years or older, respectively. Almost 60% of the individuals in this cohort had one or more underlying medical conditions, over one in three had two or more, and 20% had three or more.
Critical and fatal COVID-19 was documented in less than 8,000 veterans, including those who required intensive care unit admission or died within four weeks of testing positive for COVID-19. For other outcomes, the Moderna vaccine similarly had higher effectiveness, as it reduced hospitalizations by 77% at one month as compared to 73% for the Pfizer vaccine. At seven months, these vaccines exhibited reduced hospitalizations by 71% and 20%, respectively.
In older and sicker patients, VE declined over this time period. In those aged 65 years or over, the Moderna vaccine maintained over 70% VE against hospitalizations and ICU admissions, as well as those with two or more medical conditions. In contrast, the Pfizer vaccine was associated with less than 50% effectiveness against symptomatic, severe, or critical COVID-19 after two months.
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