The annual influenza vaccine has become less effective on average over time. One reason may be reduced vaccine efficacy in people with obesity than those with a healthier body mass index (BMI), while the number of people with high BMI grows.
Scientists at have shown that improving metabolic health in obese mice before vaccination, but not after, protects against influenza virusThe annual influenza vaccine has become less effective on average over time. One reason may be reduced vaccine efficacy in people with obesity than those with a healthier body mass index , while the number of people with high BMI grows.
"We found that the vaccines worked effectively if at the time of vaccination an animal is metabolically healthy," said corresponding author Stacey Schultz-Cherry, PhD, St. Jude Department of Host-Microbe Interactions and Center of Excellence for Influenza Research and Response co-director."And the opposite was also true: Regardless of what the mice looked like on the outside, if they had metabolic dysfunction, the vaccines did not work as well.
However, a healthy diet before vaccination improved T-cell function, which resulted in a robust anti-flu response during later exposure. "A healthy diet lowered some of the systemic meta-inflammation in these animals, and they regained some of the epithelial innate immune responses," said Schultz-Cherry."We started seeing better signaling of things like interferons, which we know is problematic in obesity and in general saw the immune system starting to function the way that it should.
The study's other authors are R. Chris Skinner, University of Vermont, Brandi Livingston, Alexandra Mandarano, Benjamin Wilander, Sean Cherry, Virginia Hargest, Bridgett Sharp, Pamela Brigleb, Ericka Kirkpatrick Roubidoux, Lee-Ann Van de Velde, Maureen McGargill and Paul Thomas, St. Jude.
Diet And Weight Loss Obesity Fitness Mice Bird Flu Research Virology Biotechnology And Bioengineering
Canada Latest News, Canada Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
BMI Honors David Foster at 2024 BMI/NAB DinnerBMI celebrated songwriter, composer and producer David Foster at the 74th annual BMI/NAB Dinner held Tuesday (April 16) at Encore Las Vegas.
Read more »
JSO: One dead, one injured, one detained after two separate Tuesday night shootings in JacksonvilleThe man in his late teens/early 20s was found with multiple gunshot wounds when officers responded, according to Jacksonville police, as another man was detained.
Read more »
Monthly Cycles of Fasting-Mimicking Diet May Slow Aging and Reduce Metabolic Disease RiskTwo clinical trials have shown that monthly cycles of a fasting-mimicking diet (FMD) can lead to lower body weight, body fat, and blood pressure at 3 months. The diet also has potential benefits for reducing the risk of metabolic syndrome and age-related diseases.
Read more »
Metabolic and Mental Health Closely LinkedMarkers of metabolic syndrome were associated with an increased risk for the three common mental health disorders up to 20 years later, results of a large longitudinal study showed.
Read more »
Doctors to focus on obesity, metabolic diseases during upcoming UT Health San Antonio eventNext Thursday, UT Health San Antonio will host the 2024 Bi-National Obesity and Metabolic Symposium.
Read more »
mRNA Technology Shows Promise in Treating Rare Metabolic DiseaseRegular infusions of messenger RNA (mRNA) coding for a missing enzyme have shown to reduce life-threatening medical emergencies in individuals with propionic acidemia, a rare metabolic disease. This study by Moderna provides the first published clinical data demonstrating the potential of mRNA technology as a drug to replace missing proteins.
Read more »