Taking low-dose aspirin to prevent heart disease and stroke is associated with an increased risk of bleeding in the skull in people without a history of those conditions, according to a new report
.
Researchers analyzed data from 13 previous studies in which over 130,000 people ages 42 to 74, who didn't have a history of heart disease or stroke, were given either low-dose aspirin or a placebo for the prevention of these conditions.An aspirin is typically defined as low-dose if it is between 75 and 100 milligrams, but most over-the-counter pills are around 81 milligrams.People who took the placebo had a 0.46% risk of having a head bleed during the combined trial periods.
Because head bleeds are often catastrophic and the benefits of low-dose aspirin are not well-established, doctors should use caution when prescribing this medication to people without symptomatic cardiovascular disease, the study's authors said.
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