A new, anti-aging vaccine is the latest breakthrough meant to extend our lifespans and healthspans. Click the link to read more. DiscoverMagazine
How long could we extend the human lifespan if geriatric problems like diabetes and heart disease were a thing of the past? Riding a wave of growing interest in longevity research, scientists in Japan recently developed a vaccine that targets the body’s— aging cells that no longer divide but can still cause chronic inflammation and disease as they accumulate in our tissues.
“Most age-related diseases involve the accumulation of senescent cells,” says Tohru Minamino, professor and chairman of cardiovascular biology and medicine at Juntendo University in Tokyo and lead author ofin December. If senescent cells accumulate in blood vessels, he explains, they cause arteriosclerosis; in the heart, they cause heart failure; and in abdominal fat, they cause diabetes.due to the COVID-19 pandemic, global life expectancy has risen dramatically in the past few decades.
But in the early 2000s, he explains, scientists realized that senescence wasn’t just an anti-cancer mechanism: These “zombie cells,” as they are sometimes referred to, accumulate with age, churn out chemicals that cause inflammation and scarring in surrounding tissue, and disrupt its function. “Like zombies, senescent cells are not dead, but they are not alive — they are not contributing to normal function,” says Macip.
Not only did it improve the lifespan of prematurely aging mice by 19 percent, but the vaccine also reduced frailty and decreased signs of metabolic disease in older mice. And when given to mice prone to hardening of the arteries, it even reversed atherosclerosis. “Our study shows for the first time that our immune system can eliminate senescent cells if adequately activated by vaccination, which is an exciting finding,” he says.
Ultimately, it may be a combination of approaches that results in an effective treatment for aging, explains David Sinclair, professor of genetics at Harvard University Medical School and author of“We showed about a year ago, for example, that we could reverse epigenetic drift and get cells to remember how to behave,” he says.
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