Researchers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to explore kinase-substrate interactions in human cellular systems.
Mount Sinai School of Medicine Oct 4 2024 Research ers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to explore kinase-substrate interactions in human cellular systems. These interactions play a vital role in modulating complex signaling pathways that control various cellular processes, such as cell growth, differentiation, and response to environmental stimuli.
Kinases are enzymes that modify other proteins by adding phosphate groups to them, a process known as phosphorylation. This modification regulates the activity, localization, and function of proteins, ultimately influencing various cellular activities. Disruption in these kinase-substrate interactions is often linked to diseases, making them major targets for therapeutic intervention.
KiNet not only aggregates existing data but also provides an interactive platform that will facilitate drug discovery and systems-level analysis." KiNet's ability to visualize kinase-substrate interactions within pathways, domain families, and custom protein sets offers researchers a powerful tool for knowledge discovery.
Kinase Cancer Cell Hospital Medicine OCT Phosphorylation Research
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