James Conner ran for two touchdowns and caught a 45-yard TD pass from backup quarterback Colt McCoy as the short-handed Cardinals beat the 49ers.
The Cardinals were playing without quarterback Kyler Murray and receivers DeAndre Hopkins and A.J. Green but still had little trouble completing the season sweep against the 49ers .
Conner finished with 173 yards from scrimmage and now leads the NFL in TDs with 11, all scored in the past seven games. The Niners are now winless in four home games this season and are just 1-8 at Levi's Stadium the past two seasons. San Francisco trails Arizona by four games in the NFC West and can afford a few more slipups if the 49ers hope to make a wild-card push.
George Kittle then fumbled after a catch on the first play of the second drive. San Francisco punted again on the third drive and Brandon Aiyuk lost a fumble on the fourth drive.The Cardinals set up their second TD with a trick play. Receiver Christian Kirk got the ball on an end-around and launched a deep pass that Antoine Wesley caught for a 33-yard gain to the 1. It was Kirk's first completion in college or the pros.
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