Phenotypic analyses revealed the role of plasma lipids in mediating the interactions between genetic and environmental factors associated with Autism-related traits in children doyouseewhy UQ_News
Our findings have potential clinical implications. There may be a role for dietary LC-PUFAs or omega-3 or -6 supplementation in sleep disturbances. We also highlight the imperative to screen for and manage sleep disturbances among children with neurodevelopmental differences, having found convergence in the sleep disturbances lipidome with dietary habits that may predispose to long-term health problems, as well as possible associations with poorer adaptive function.
There are some limitations to this work. The sample collection protocol did not include fasting . We attempted to overcome this by performing sensitivity analyses with cosine-transformed sample collection times, to account for cyclical patterns in lipid concentrations, and did not find major differences in the results. Clinical lipids were not directly measured and were instead inferred using lipidomics measures.
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