Nanofitins, which are derived from a protein found in Sulfolobus acidocaldarius—an archaeal microorganism found in hot springs—successfully neutralized SARS-CoV-2 in mice and were well-tolerated. When inhaled by the rodents, the engineered nanofitins, which inhibit the virus by binding to its spike proteins, were observed to quickly reach the lungs in high doses both preventing and clearing early infections, researchers from biotech company Affilogic report Aug. 30 in the journal Molecular Therapy.
These are lung histological pictures reflecting cell infiltration in the different setups. Black arrows indicate the cell infiltrations around blood vessels and bronchi. Scale bar, 500 mm. Credit: Viollet and Enouf et al./Molecular Therapy
Nanofitins, which are derived from a protein found in Sulfolobus acidocaldarius—an archaeal microorganism found in hot springs—successfully neutralized SARS-CoV-2 in mice and were well-tolerated. When inhaled by the rodents, the engineered nanofitins, which inhibit the virus by binding to its spike proteins, were observed to quickly reach the lungs in high doses both preventing and clearing early infections, researchers from biotech company Affilogic report Aug.
If approved for use in humans, nanofitin technology could offer a noninvasive alternative with immediate inhibition of viral load present in the lung tissues. Because the molecules are relatively small and very thermostable, their resistance to high temperatures and a wide range of pH values could help streamline manufacturing and formulation.
"The nanofitin technology is very adaptive and could be implemented in other infectious respiratory diseases, increasing the number of biologics administered directly into the lung for fast action and ease of use," Viollet says."This is of particular interest for populations with limited tolerance to repeated injections, such as infants and elderly people.
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