The skin-lightening ingredient is now available only with a prescription.
, says hydroquinone’s initial link to cancer came from a study of rats and mice that had been force-fed the drug, resulting in some evidence of carcinogenic activity for male and female rats and female mice. “But it is important to note that these findings stemmed from largedoses over extended time periods,” says Westbay. “There is no reported cancer data in humans with the use of topical hydroquinone.
When used under close supervision with the guidance of a doctor, prescription hydroquinone remains a trusted, effective ingredient many dermatologists rely on. “It is still used as the most common prescription treatment for hyperpigmentation across the country,” says Bhanusali, adding that many dermatologists have voiced their disagreement over its being banned in OTC products.
Fastidious sunscreen application is particularly important when using hydroquinone. Westbay says that, according to a study presented at the’s annual meeting last year, hydroquinone use was found to increase the risk of both melanoma and nonmelanoma skin cancers by more than threefold. “This is not likely to be a direct consequence of hydroquinone toxicity,” Westbay explains.
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