The stress-induced mechanisms that cause our brain to produce feelings of fear in the absence of threats -- such as in PTSD -- have been mostly a mystery. Now, neurobiologists have identified the changes in brain biochemistry and mapped the neural circuitry that cause generalized fear experiences.
Neurobiologists uncover how stress turns into fear in the brain -- in conditions such as PTSD -- and a method to block it
The stress-induced mechanisms that cause our brain to produce feelings of fear in the absence of threats have been mostly a mystery. Now, neurobiologists at the University of California San Diego have identified the changes in brain biochemistry and mapped the neural circuitry that cause such a generalized fear experience.
Building upon this new finding of a stress-induced switch in neurotransmitters, considered a form of brain plasticity, the researchers then examined the postmortem human brains of individuals who had suffered from PTSD. A similar glutamate-to-GABA neurotransmitter switch was confirmed in their brains as well.
Not only did the researchers identify the location of the neurons that switched their transmitter, but they demonstrated the connections of these neurons to the central amygdala and lateral hypothalamus, brain regions that were previously linked to the generation of other fear responses.
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