The case of a patient with HIV whose viral load dropped to undetectable levels and whose immune cells soared has captured the attention of HIV experts.
July 29, 2022
Although the 59-year-old woman is one of many who are known as post-treatment controllers — having been in remission for more than 15 years after stopping antiretroviral therapy — it is an immune-based therapy study in which she took part in 2005, and her unusually high levels of memory-like NK cells and gamma-delta T cells since then, that are raising some eyebrows.
The findings suggest the potential for"increasing the amount of those memory-like NK cells and gamma-delta T cells in order to translate this potent antiviral activity in new therapies to achieve an HIV functional cure," she said, adding,"As far as we know, aiming to increase these specific cells has never been done before in people living with HIV."
"None of the other 19 patients included in the trial controlled viral replication," senior investigator Jose Miro, MD, PhD, also from Hospital Clinic-IDIBAPS/University of Barcelona, HIV Unit, Barcelona, Spain, toldSharon Lewin, MD, president-elect of the International AIDS Society , which runs the conference, told Medscape that although the significance of the case is unclear, the IAS selected it as a highlight for the meeting.
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