A common HIV drug has been shown to improve the connections between memories in aging mice. The findings could help reveal how contextual events are remembered in the human brain, and why this becomes harder as we age.
connects with one of these receptors, it can enter the cell and replicate. But if maraviroc gets there first, it blocks the entrance.that maraviroc can also help neurons to make new connections following a stroke.
The hippocampus is the brain's hub for memory formation, but a gradual increase in CCR5 expression makes it harder for neurons to link one memory to another based on context. Importantly, some mice in the study were introduced to context A and context B within five hours of each other. Others were introduced to both contexts with a one, two, or seven day separation.
None of the mice were able to link context A to context B as effectively when the introductions were separated by two or more days. Only when CCR5 was knocked out in some mice, the animals were able to do so.
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