These potential COVID-19 vaccines are being tested in humans
announced on March 16 that they had given their potential vaccine to the first person in their clinical trials. The first phase of their trial aimed to enroll 45 healthy volunteers between 18 and 55 years old and was expected to take approximately six weeks. Their vaccine is designed by using the sequence of the virus, which was shared by Chinese authorities in early January, instead of working on the virus itself.
On May 18, they shared the results of their first phase of trials, led by the National Institute of Allergy and Infectious Diseases. One of the biggest aspects of their first phase was testing different levels of dosage, all measured in micrograms. At the lowest dosage level, 25 micrograms, participants were found to have a comparable level of binding antibodies in their system by day 43 as the number of binding antibodies found in people recovering from COVID-19.
One individual who received a lower dose developed redness around the site of injection, but the highest number of adverse effects were felt at the highest dosage: 250 micrograms. Three individuals had “grade 3 systemic symptoms” following their second dose of the vaccine, accordingBased on this data, Moderna’s phase two will study two dosage levels: 50 micrograms and 100 micrograms.
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