A study involving thousands of people in Finland has identified a potential microbial culprit in some cases of depression. WeekendReads
, but just which microbes are the key actors has been elusive. Now, a study involving thousands of people in Finland has identified a potential microbial culprit in some cases of depression.
The finding, which emerged from a study of how genetics and diet affect the microbiome, “is really solid proof that this association could have major clinical importance,” says Jack Gilbert, a microbial ecologist at the University of California, San Diego, who was not involved with the work.between brain conditions and gut microbes. People with autism and mood disorders, for example, have deficits of certain key bacteria in their guts.
Méric and his colleagues combed the data for clues to how a person’s diet and genetics affect the microbiome. “There have been very few studies that have examined [all these factors] in such detail,” Gilbert says. Two sections of the human genome seemed to strongly influence. One contains the gene for digesting the milk sugar lactose, and the other helps specify blood type.
Méric’s team also explored which genetic variants might affect the abundance of certain microbes—and which of those variants were linked to 46 common diseases. When it came to depression, two bacteria that cause infections in hospitalized patients,
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