There is 'good evidence' that drugs to treat attention deficit hyperactivity disorder (ADHD) might also successfully treat key aspects of Alzheimer's disease, finds a pooled data analysis of the available research, published online in the Journal of Neurology Neurosurgery & Psychiatry.
published between 1980 and 2021 in which noradrenergic drugs, such as atomoxetine, methylphenidate, and guanfacine, had been used to potentially improve cognitive and/or neuropsychiatric symptoms in people with neurodegenerative disease.mild cognitive impairment
The results of 10 of these trials, involving 1300 patients, were pooled for global cognition—orientation/attention, memory, verbal fluency, language and visuospatial ability. The results of 8 clinical trials, involving 425 patients, were then pooled for behavior and neuropsychiatric symptoms, agitation and apathy. And this showed a large positive effect of noradrenergic drugs on apathy, even after removing outliers to account for differences in trial design and intended outcomes.in Alzheimer's disease for general cognition and apathy," say the researchers.
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