What does the inside of a cell really look like? In the past, standard microscopes were limited in how well they could answer this question. Now, researchers have succeeded in developing a microscope with resolutions better than five nanometers (five billionths of a meter).
What does the inside of a cell really look like? In the past, standard microscopes were limited in how well they could answer this question. Now, researchers have succeeded in developing a microscope with resolutions better than five nanometers . This is roughly equivalent to the width of a hair split into 10,000 strands.
This type of microscope is known as a fluorescence microscope. Their function relies on"single-molecule localization microscopy," in which individual fluorescent molecules in a sample are switched on and off and their individual positions are then determined very precisely. The entire structure of the sample can then be modelled from the positions of these molecules. The current process enables resolutions of around 10 to 20 nanometres.
Niels Radmacher, Oleksii Nevskyi, José Ignacio Gallea, Jan Christoph Thiele, Ingo Gregor, Silvio O. Rizzoli, Jörg Enderlein.A team has constructed an improved mid-infrared microscope, enabling them to see the structures inside living bacteria at the nanometer scale. Mid-infrared microscopy is typically limited by its low ...
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