The researchers call it a medical first.
Isabelle Carnell-Holdaway, 17, has faced not one but two unrelenting threats to her life. Diagnosed at 11 months of age with cystic fibrosis, the progressive genetic disease that causes lung infections and breathing impairment, Isabelle has also combated an on-again, off-again infection caused by antibiotic-resistant bacteria since age 8.
"Children with cystic fibrosis are very prone to picking up all sorts of nasty infections," said her mother, Jo Carnell-Holdaway. By the time she was 14, Isabelle's lung function was about 25% or 30%, according to her mother. In September 2017, at 15, she underwent a double lung transplant, as recommended by her doctor Dr. Helen Spencer, a respiratory pediatrician and lead for the lung transplant service at Great Ormond Street Hospital in London.
Schmidt notes that pharmaceutical companies, including Johnson & Johnson, have begun to invest in potential phage therapeutics, while scientists believe the field is better positioned today with faster, cheaper genetic screening and greater understanding of phage pharmacology. Still, production costs"pose a major hurdle," and much remains unknown about phage biology.
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