Brain disruptions that may contribute to autism could be happening in the first three months of fetal development.
When the Memo1 gene was mutated, the radial glia, instead of growing single fibers that went from the bottom to the top of the cortex, sprouted extra fibers that went willy-nilly in a variety of directions. That led to nerve cells sometimes ending up in the wrong place and layers that were disorganized.
“These radial glia are the stem cells of the brain,” Sestan, who was not involved in the new study, said. “They create all the neurons in the cortex and guide them to their final destination.”
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