A drug called Leqembi, which modestly slows progression of the disease, is expected soon to receive full approval from federal regulators. Skeptics note, however, that the drug’s effectiveness is limited.
Thomas M. Wisniewski, a neurologist at NYU Langone Health, called Leqembi a major breakthrough for the amyloid cascade hypothesis — the long-debated view that removing amyloid from the brain can slow Alzheimer’s — “but also for the field in general that therapies are possible for Alzheimer’s.”
Fix was prescribed Aricept, which treats symptoms such as memory loss and thinking problems but has side effects. She ended up hospitalized with atrial fibrillation. Still unresolved is one of the biggest questions involving Leqembi: How will patients get the drug if they don’t typically go to big medical centers? That includes rural patients and African Americans and Latinos, who typically receive less Alzheimer’s care than their White counterparts.to cover Leqembi and similar drugs that receive traditional FDA approval, but with a caveat: Physicians must participate in registries that collect evidence about how the drugs work in the real world.
Covinsky, the UCSF geriatrician, said it was “absurd to pay all this money for a drug” when other steps — such as providing Medicare coverage for home health aides — would be more helpful to patients and families. Now, after a period of relative stability, Reinstein, who still lives in Durham, fears his illness may be accelerating. On a weekly talk radio show he co-hosts, he finds the off-the-cuff debates increasingly difficult. He recently failed a driving simulator test at the Memory Disorders Clinic of Duke University Health Systems in North Carolina, where he is being treated. The occupational therapist ordered him to take an Uber home.
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