Up to 17 months later, five lupus patients have remained free of damaging autoantibodies after receiving CAR T cell therapy.
, caused by a wayward immune system, that affects about 1.5 million Americans. There are several forms of lupus, some of which affect specific parts of the body, such as the skin. But the most common version is systemic lupus erythematosus , which can affect nearly every organ in the body. Symptoms of SLE often vary from person to person, and it may take years for someone to know that they have lupus.
Most cases of lupus are diagnosed between the ages of 15 and 44 and have no clear cause, though it’s suspected that a person’s genetics and environmental triggers like viral infection play a vital role. Once symptoms occur, people will tend to experience flare-ups of illness. These flare-ups can be lessened or managed with treatments, but there is currently no cure for lupus itself.The underlying defect behind lupus are antibodies that attack the body’s tissues.
The basic concept of CAR T cell therapy is to take a person’s T cells—immune cells trained to attack a specific target, like a foreign germ—and modify them in the lab to recognize targets on a cell’s surface that they would normally have trouble finding, such as those on certain cancer cells.
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