First Canadian clinical trial of any COVID-19 vaccine is launched in Quebec City

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First Canadian clinical trial of any COVID-19 vaccine is launched in Quebec City
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Quebec City experiments on humans a vaccine that has shown positive results in animals

RNA VACCINECoronavirus proteins produced within host cells are now free to be taken up and presented to immune system like a protein-based vaccine.MURAT YÜKSELIR AND IVAN SEMENIUK / THE GLOBE AND MAIL

But with the possibility that any of these front-runners may ultimately fail, or that Canada will be unable to secure its own supply ahead of other countries, experts stress the need for home-grown options.“Hopefully we’ll have multiple successes within Canada so that there are multiple manufacturers with the capability of supplying Canadian requirements,” said Scott Halperin, director of the Canadian Centre for Vaccinology in Halifax.

The worry lurking in the background is that the delay is a harbinger of what lies ahead as various vaccine candidates begin coming online and international partnerships come up against domestic plans and priorities. VIDO-InterVac in Saskatchewan, one of Canada’s largest infectious disease centres and the first in the country to successfully isolate the virus that causes COVID-19, may come next with a vaccine candidate the centre says could be ready for human trials by October.

Genetic instructions for making the particles are provided to a plant – a relative of tobacco – which dutifully churns out the particles as though it were making something required by its own metabolism. The ruse works for only a week or so, Dr. Landry said, after which “we harvest, crush up the leaves and purify the vaccine.”

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