In Cuyahoga County, 18 people died from the mixture in 2022, up from 15 in 2021, according to the county medical examiner’s office. Earlier this year, Gov. Mike DeWine signed an executive order that made xylazine a controlled substance under state law.
Gupta said xylazine slows breathing and heart rate to unsafe levels, and makes it harder to use naloxone to revive people who overdose on fentanyl because xylazine is not an opioid. He stressed that naloxone should still be given to people who are overdosing on both drugs due to its lifesaving effects for fentanyl.
Gupta said the administration is also developing a way to treat xylazine addiction and best practices to treat the flesh wound it creates. Lastly, it is examining how to schedule xylazine as a controlled substance while maintaining a legitimate supply for veterinary use. The National Response Plan also notes practical steps states and individuals can take to help address this issue:
• Addiction treatment and emergency responders should consult with experts on xylazine detoxification methods to understand emerging practices.
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