In a mid-stage trial, the highest dose of Eli Lilly's experimental pill orforglipron led to 14.7% weight loss after 36 weeks for people who were obese or overweight, setting a marker in the race to develop effective oral obesity drugs, researchers said on Friday.
Eli Lilly logo is shown on one of the company's offices in San Diego, California, U.S., September 17, 2020. REUTERS/Mike Blake/File Photoexperimental pill orforglipron led to 14.7% weight loss after 36 weeks for people who were obese or overweight, setting a marker in the race to develop effective oral obesity drugs, researchers said on Friday.
Both drugs belong to a new class known as incretins that have reignited researcher and investor interest in the weight-loss treatment market, which is estimated to reach $100 billion by the endAt the multi-dose trial's 26-week main endpoint, Lilly said once-daily orforglipron showed statistically significant dose-dependent body weight reductions ranging from 8.6% to 12.6% , compared with 2% for the placebo group.
Lilly said the safety profile of orforglipron was similar to other incretin-based therapies, with gastrointestinal side effects the most common, generally mild-to-moderate and usually occurring during the initial dose escalation period.Ozempic and Wegovy, are designed to activate hormones that regulate blood sugar, slow stomach emptying and decrease appetite.
“We recognize that obesity is a global epidemic and there is a need for a variety of effective medications and administration routes,” weight-loss specialist Dr. Sean Wharton said in a statement.
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