Supervised exercise combined with obesity pharmacotherapy helped maintain weight loss for up to a year after treatment termination, a study published in The Lancet showed.
Despite significant weight loss achieved with incretin-based obesity pharmacotherapies, their high costs and gastrointestinal adverse events lead to high discontinuation rates with subsequent regaining of weight and body fat.-like peptide-1 receptor agonist, was better than either intervention alone in terms of maintaining weight loss and body composition after treatment termination.
They conducted a 1-year posttreatment analysis of the S-LiTE study, including 109 adults with obesity who completed an 8-week low-calorie diet resulting in ≥ 5% weight loss. Participants were then randomly allocated to a 52-week weight loss maintenance intervention with either liraglutide or placebo alone or liraglutide or placebo plus supervised exercise.
The primary outcome was the change in body weight from randomization to 1 year after the termination of weight maintenance intervention , and the secondary outcome was the change in body-fat percentage from 0 to 104 weeks.During the 1 year after treatment termination , those in the liraglutide group regained 6 kg more than those who were in the supervised exercise plus placebo group, and 2.5 kg more than those who received supervised exercise plus liraglutide.
After 1 year of treatment termination , the supervised exercise plus liraglutide group had significantly higher odds of maintaining a weight loss of ≥ 10% of initial body weight than the liraglutide or placebo groups.
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