The antibody treatment donanemab slows clinical decline by around a third, a large trial confirms.
In the donanemab trial, researchers examined 1,736 people aged 60 to 85 with early-stage Alzheimer's.
The pace of the disease, judged by what people could still do day-to-day, was slowed by about 20-30% overall - and by 30-40% in a set of patients who researchers thought more likely to respondHalf of patients on donanemab were able to stop the treatment after a year, because it had cleared sufficient brain deposits
Dr Susan Kohlhaas, from Alzheimer's Research UK, said: "Today's announcement marks another milestone. Thanks to decades of research, the outlook for dementia and its impact on people and society is finally changing, and we're entering a new era where Alzheimer's disease could become treatable." Asked if the government were prepared to invest where needed to roll out new treatments, Mr Cameron said there was a real incentive to do so: "We're a country of sixty million people with a million people with dementia, many of them in very expensive residential care settings and so there is a lot of savings to be had from effectively treating people….I'm hopeful that our system can deliver.
Dr Emer MacSweeney, consultant neuroradiologist and medical director at Re:Cognition Health, led the trials of donanemab in the UK.The Alzheimer's Society said: "This is truly a turning point in the fight against Alzheimer's and science is proving that it is possible to slow down the disease."
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