“The report tells us a lot about the culture and realities of the way cancer biology works, and it's not a flattering picture at all.” WorldCancerDay
The team also measured if a replication was successful using five criteria. Four focused on effect sizes, and the fifth looked at whether both the original and replicated experiments had similarly positive or negative results, and if both sets of results were statistically significant. The researchers were able to apply those criteria to 112 tested effects from the experiments they could reproduce. Ultimately, just 46 percent, or 51, met more criteria than they failed, the researchers report.
The overarching lessons of the project suggest that substantial inefficiency in preclinical research may be hampering the drug development pipeline later on, says Tim Errington, who led the project. He is the director of research at the Center for Open Science in Charlottesville, Va., which cosponsored the research.never receive approval from the U.S. Food and Drug Administration.
Scientists still have to evaluate whether a study’s methods are unbiased and rigorous, says Wang, who was not involved in the project but reviewed its findings. And if the results of original experiments and their replications do differ, it’s a learning opportunity to find out why and the implications, she adds., but this is the first time that the effort’s entire analysis has been released .
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