Does vaccine- or infection-induced immunity protect less well against infection by specific SARS-CoV-2 variants? ScienceMagazine rivm COVID19 coronavirus covid SARSCoV2 infection vaccine vaccination
By Tarun Sai LomteJul 28 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in Science Translational Medicine, researchers found that vaccinated people were at an increased risk of infection with severe acute respiratory syndrome coronavirus 2 Beta, Gamma, or Delta variants.
About the study In the present study, researchers assessed whether infection- or vaccination-induced immunity was less protective against infection by specific SARS-CoV-2 variants. The central objective of the study was to investigate if there was a higher risk of infection with Beta, Gamma, or Delta variant relative to Alpha variant in those with pre-existing vaccine/infection-induced immunity.
A multinomial logistic regression analysis assessed the association between the risk of infection by the specified VOC and the immune status. Odds ratios were computed with 95% confidence intervals for any vaccine type and individually for each vaccine. An OR greater than one meant less protection by pre-existing immunity from infection by the indicated variants relative to the Alpha variant.
Regression analysis revealed a significant association between complete vaccination and Beta, Gamma, or Delta variant infection relative to Alpha infection. There was a less robust and non-significant association of partial vaccination with Beta or Gamma variant infection but significant for infection by Delta variant.
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