The study found that men who had high fiber intake and high blood bile acid levels had a 40% higher risk of liver cancer. Fiber-enriched foods are often consumed by many individuals to promote weight loss and fend against chronic diseases like cancer and diabetes. Consuming highly refined fiber
The results highlight both the need for routine blood bile acid level testing as well as caution when individuals with high bile acid levels consume fiber.
“We have worked for a long time on this idea that all diseases start from the gut,” said Dr. Matam Vijay-Kumar, a professor in the Department of Physiology and Pharmacology in the College of Medicine and Life Sciences and the paper’s senior author. “This study is a notable advancement of that concept. It also provides clues that may help identify individuals at a higher risk for liver cancer and potentially enable us to lower that risk with simple dietary modifications.
“That was very surprising, given how rarely liver cancer is observed in mice,” said Vijay-Kumar, who is also director of the UToledo Microbiome Consortium. “The findings raised real questions about the potential risks of certain refined fibers, but only now do we understand why the mice were developing such aggressive cancer.”
Blood that’s diverted away from the liver contains high levels of microbial products that can stimulate the immune system and cause inflammation. “Dietary inulin is good in subduing inflammation, but it can be subverted into causing immunosuppression, which is not good for the liver,” said Dr. Beng San Yeoh, a postdoctoral fellow and the new paper’s first author.
In the 224 men who went on to develop liver cancer, their baseline blood bile acid levels were twice as high as men who did not develop liver cancer. Statistical analysis also found individuals with the highest blood bile acid levels had a more than four-fold increase in the risk of liver cancer. Intriguingly, researchers found high total fiber intake reduced the risk of liver cancer by 29% in those whose serum bile acid levels were in the lowest quartile of their sample.
Canada Latest News, Canada Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Watch 1 Billion Years of Shifting Tectonic Plates in 40 Mesmerizing SecondsThe tectonic plates that cover Earth like a jigsaw puzzle move about as fast as our fingernails grow, but over the course of a billion years that's enough to travel across the entire planet – as a fascinating video reveals.
Read more »
GOP Would Undermine 40 Million Student Debtors to Gain Midterm LeverageThe legal challenge is part of a broader GOP strategy to delay debt forgiveness until after the midterms.
Read more »
US emergency oil supply shrinks to 40-year lowProponents of releasing barrels from the emergency stockpile say it increases oil supplies and reduces prices at the pump. Critics say it's a short-term fix.
Read more »
The 40 Best K-Pop Deep Cuts of the Decade So Far: Critics’ PicksThese 40 selections confront the misconception that K-pop is solely manufactured bubblegum pop.
Read more »
No. 8 Tennessee makes statement with 40-13 blowout win over No. 25 LSUNo. 8 Tennessee made a statement on Saturday.
Read more »
Family Hesitant About Sinking Another 40 Grand Into Repairs Of Dilapidated Old GrandmaCALDWELL, ID—Conceding that she just might not be worth the expense at this point, the Smith family told reporters Monday that they were hesitant about sinking another $40,000 of repairs into their dilapidated old grandmother. “I hate to say it, but we might just be throwing money away on the old girl,” said her son…
Read more »