Stem-cell therapy has promise in the treatment of high-risk type 1 diabetes. A clinical study presented at ENDO 2022, the Endocrine Society's annual meeting in Atlanta, Georgia, suggests that an investigational stem cell-based therapy called PEC-Direct, intended to function as a replacement pancrea
The findings suggest stem cell-based replacement therapy has the potential to manage blood sugar levels and may eventually replace the requirement for external insulin injections or dosing.A clinical study presented at ENDO 2022, theannual meeting in Atlanta, Georgia, suggests that an investigational stem cell-based therapy called PEC-Direct, intended to function as a replacement pancreas, has the potential to provide blood sugar control in patients with high-risk type 1 diabetes.
“This research represents the first instance in multiple patients of clinically relevant increases in C-peptide, indicative of insulin production, with a stem cell-based therapy delivered in a device,” according to Manasi Sinha Jaiman, M.D., M.P.H., Chief Medical Officer of ViaCyte, Inc., in San Diego, Calif., the company that makes PEC-Direct.
The PEC-Direct device is intended to provide a consistent, long-term source of insulin to control blood sugar levels. The system consists of a pouch containing pancreatic cells produced from stem cells that, when implanted in the body, develop into cells that produce insulin. The device’s open membrane enables blood vessels to grow into it to contact the cells. Patients use immunosuppressive drugs to prevent an immune reaction.
The study included 10 adults with type 1 diabetes who had received their diagnosis at least 5 years prior to the start of the study and were not able to tell when their blood sugar went too low . Initial data from one patient showed clinically relevant levels of stimulated C-peptide and corresponding improvements in blood glucose control within six months after implantation of PEC-Direct.
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