Early research suggests that monoclonal antibodies—used to protect the vulnerable from COVID-19—may provide non-addictive, long-lasting pain relief from a variety of conditions
, which funds a wide array of research into preventing opioid addiction and developing safer, effective non-opioid pain treatments.
“In terms of chronic pain, we’ve got to figure something out because it’s difficult to treat and there aren’t a lot of great options,” says Ryan Marino, a medical toxicologist and addiction medicine specialist at Case Western Reserve University in Cleveland. “Opioids lose their effectiveness with long-term use for a lot of people, and there’s a potential for dependency to develop. Even if you’re taking them as prescribed, you will have to take higher and higher doses to get pain relief.
Unlike previous generations of mAbs, the ones in development for chronic pain are designed for self-administration and home use; there’s no need for an infusion at a medical facility as there is for COVID-19. And “you don’t have to worry about people becoming dependent on them or that they’ll lose their effectiveness,” Marino adds.
While this has been one of the biggest success stories so far when it comes to the use of mAbs for chronic pain, it’s not a slam-dunk victory. Clinically, “we don’t see most people having 100 percent relief with CGRPs for [chronic] migraine,” says Argoff. In fact, afound that when people with chronic migraine used anti-CGRP monoclonal antibodies, approximately 61 percent of them saw the number of migraine days reduced by at least half. In other words, the mAb helped, but it wasn’t a cure.
Unfortunately, the tanezumab study also found that 2.6 percent of the people who received the 10 milligram dose of the drug experienced an acceleration of osteoarthritis. That’s why theDespite the tanezumab setback, experts are optimistic that other mAbs can be developed to target various forms of chronic pain. Eventually, the hope is that mAbs can be created to treat neuropathic pain and inflammatory pain , Yarov-Yarovoy says.
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