Taking oral or inhaled glucocorticoids, a type of steroid used to curb inflammation in asthma and other autoimmune disorders, may be linked to damaging changes in the white matter of the brain, a new study found.
Allergies, asthma linked to heart disease, study says"This study shows that both systemic and inhaled glucocorticoids are associated with an apparently widespread reduction in white matter integrity," wrote study author Merel van der Meulen, a postdoctoral student at Leiden University Medical Center in the Netherlands, in the study published Tuesday in the journal BMJ Open.White matter is the tissue that forms connections between brain cells and the rest of the nervous system.
From that database, the researchers were able to find 222 oral glucocorticoid users and 557 users of inhaled glucocorticoids who did not have a previous diagnosis of any neurological, hormonal or mental health disorder. Those people underwent cognitive and mental health testing and received a diffusion MRI of the brain. Researchers pulled that data and compared those MRI and cognitive findings to over 24,000 people in the database who did not use steroids.
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