Cognition Can Be Boosted in Some Patients With Down Syndrome, Study Finds

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Cognition Can Be Boosted in Some Patients With Down Syndrome, Study Finds
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A new hormone treatment improved the cognitive function of six men with Down Syndrome by 10-30 percent, scientists said Thursday, adding the 'promising' results may raise hopes of improving patients' quality of life.

Down Syndrome is the most common genetic form of intellectual disability, occurring in around one in 1,000 people, according to theYet previous research has failed to significantly improve cognition when applied to people with the condition, which is why the latest findings are"particularly important", the study said.

"We wondered if this hormone could play any role in establishing the symptoms of people with Down Syndrome," said Vincent Prevot, study co-author and head of neuroscience research at France's INSERM institute.The team first established that five strands of microRNA regulating the production of GnRH were dysfunctional in mice specifically engineered for Down Syndrome research.

"We have seen an improvement of between 10-30 percent in cognitive functions, in particular with visuospatial function, three-dimensional representation, understanding of instructions as well as attention," Pitteloud said. "We are not going to cure the cognitive disorders of people with Down Syndrome, but the improvement seen in our results already seems fundamental enough to hope to improve their quality of life," Pitteloud said.

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