Nature research paper: Co-opting signalling molecules enables logic-gated control of CAR T cells
Extended Data Fig. 2 ZAP-70 CAR T cells show potent in vitro and in vivo activity., Representative flow cytometric plots of CAR, LAG-3, TIM-3, and PD-1 expression for T cells bearing CD19 or HER2-specific CARs containing 4-1BBζ or ZAP-70, IFNγ secretion by GD2-4-1BBζ and GD2-ZAP-70CAR T cells following 24-h culture in the absence of target cells. Shown are mean values ± s.d. of three experimental replicates. Representative of three experiments with different blood donors.
human neuroblastoma CHLA-255 cells co-cultured with B7-H3 or GD2-specific CAR T cells containing ZAP-70or 4-1BBζ endodomains at a 1:1 ratio of T cells to tumour cells. Shown are mean values ± s.d. of three experimental replicates. Representative of four independent experiments with different blood donors.T cells recovered from the bone marrow of CHLA-255-bearing mice on days 7 and 14 after treatment with 1 x 10CAR T cells 7 days after tumour inoculation. Shown are mean values ± s.e.m.
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