Chemists create nanomachines by breaking them apart NatureChemistry
Lauzon and Vallée-Bélisle found that the function of molecular nanomachines can efficiently evolve by breaking them into multiple components. The image illustrates how the fabrication of nanomachines using one green component leads to a simple functional unit while the fabrication of similar nanomachines using three components allows creating functional units with novel regulation properties .
Studying the way these nanomachines are built, Vallée-Bélisle, holder of the Canada Research Chair in Bioengineering and Bio-Nanotechnology, noticed that while some are made using a single"Since most of my students spend their lives creating nanomachines, we started to wonder if it is more beneficial to create them using one or more self-assembling molecular components," said Vallée-Bélisle.
Lauzon and Vallée-Bélisle spent years performing the experimental validations. They were able to demonstrate that nanomachines could easily withstand fragmentation, but more importantly, that such a destructive event allowed for the creation of various novel functionalities, including different sensitivity levels towards variation in component concentration, temperature and mutations.
"Overall, these novel functionalities were created by simply cutting up, or destroying, the structure of an existing
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