Monoclonal antibodies added to allergy shots may give cat allergy sufferers more relief than shots alone do.
Despite their long use, scientists don’t know exactly how allergy shots work, says Lisa Wheatley, an allergist at the National Institute of Allergy and Infectious Diseases. Some people are essentially cured of their allergies, while others may need shots indefinitely. “We knew that if you were on immunotherapy for cat [allergies] … you will be better after that year, but you will not retain that benefit.
When allergies strike, some immune cells produce alarm chemicals that trigger inflammation and other symptoms. “If we could dampen the signaling that says ‘danger,’ we could maybe improve immunotherapy,” Wheatley says. Researchers gave 121 cat allergy sufferers either standard allergy shots alone, tezepelumab alone, a combination of the two or a placebo. On its own, tezepelumab was no better than just a placebo, the researchers found.to cat dander squirted up their noses compared with people who got standard shots, researchers report October 9 in theAnd levels of allergy-triggering antibodies called IgE fell and kept falling even a year after treatment stopped in people who got the combination.
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